Anti-Retinal and Optic Nerve Antibodies

Robert B. Darnell and Jerome B. Posner

in Paraneoplastic Syndromes

Published on behalf of Oxford University Press

Published in print April 2010 | ISBN: 9780199772735
Published online April 2013 | e-ISBN: 9780199322916 | DOI:

Series: Contemporary Neurology Series

Anti-Retinal and Optic Nerve Antibodies

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Antibodies to retinal and optic nerve antigens caused by cancer are usually encountered in one of two settings.4 The first, carcinoma-associated retinopathy (CAR),5 is caused by several different tumors (Table 14–3); blindness often precedes discovery of the tumor by months or years. The disorder is associated with a number of antibodies; recoverin6 and anti-enolase7 are the most common ones. One antibody recognizes polypyrimidine tract-like binding protein (PTPLP), also known as brPTB or nPTB, first described as neuron-specific proteins that interact with the paraneoplastic antigen Nova (Chapter 11). As a rule, CAR is associated with photoreceptor degeneration, sparing the inner retina, and documented by the presence of antineuronal antibodies and abnormal ERGs. The second disorder, MAR,8 is, as the name implies, associated with melanoma; blindness usually occurs in patients already known to have cancer. These and other paraneoplastic syndromes affecting the retina and optic nerve are discussed Chapter 7. The associated antibodies are described in detail in this chapter.

Chapter.  7009 words.  Illustrated.

Subjects: Neurology

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