Breast, Gynecologic, and Testicular Cancers

Robert B. Darnell and Jerome B. Posner

in Paraneoplastic Syndromes

Published on behalf of Oxford University Press

Published in print April 2010 | ISBN: 9780199772735
Published online April 2013 | e-ISBN: 9780199322916 | DOI:

Series: Contemporary Neurology Series

Breast, Gynecologic, and Testicular Cancers

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After small-cell lung cancer (SCLC) and thymoma, ovarian cancer probably has the highest incidence of paraneoplastic syndromes. Unlike SCLC and thymoma, in which multiple paraneoplastic syndromes associated with multiple paraneoplastic antibodies are common, most patients with ovarian and other gynecologic cancers suffer from one of two paraneoplastic syndromes: paraneoplastic cerebellar degeneration (PCD) associated with the anti-Yo antibody (Chapters 5 and 12) or paraneoplastic encephalomyelitis associated with ovarian teratoma (usually benign) and the anti-NMDAR antibody (Chapters 4 and 13). Other paraneoplastic syndromes sometimes occur, but they are decidedly rare. Paraneoplastic syndromes associated with breast cancer are far more diverse and can be associated with several antibodies. Most patients with testicular cancer suffer from a single paraneoplastic syndrome, encephalomyelitis affecting brainstem and hypothalamus with anti-Ma2 antibodies (chapters 4 and 11).

Chapter.  4184 words.  Illustrated.

Subjects: Neurology

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