Functional Brain Imaging in Bipolar Disorder

Lori L. Altshuler and Jennifer D. Townsend

in The Bipolar Brain

Published on behalf of Oxford University Press

Published in print July 2012 | ISBN: 9780199797608
Published online June 2013 | e-ISBN: 9780199323135 | DOI:
Functional Brain Imaging in Bipolar Disorder

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The prefrontal cortex (PFC) integrates and regulates emotional responses. Diminished subcortical and limbic modulation and frontolimbic abnormities may represent substrates for the acute mood episode characteristic of bipolar disorder (BP).

This chapter will review fMRI studies performed in subjects with bipolar disorder during manic, depressive or euthymic states. Paradigms using tasks that probe emotion processing, emotion regulation, executive function, working memory and response inhibition have been used to assess activation in specific brain regions. Some abnormalities appear to be state related while others may represent enduring trait deficits.

Chapter.  19208 words.  Illustrated.

Subjects: Psychiatry ; Neuroscience

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