Pharmacokinetics and Pharmacodynamics of Antimicrobials

Lynn L. Estes

in Mayo Clinic Infectious Diseases Board Review

Published on behalf of © Mayo Foundation for Medical Education and Research

Published in print January 2012 | ISBN: 9780199827626
Published online June 2012 | e-ISBN: 9780199929641 | DOI:

Series: Mayo Clinic Scientific Press

Pharmacokinetics and Pharmacodynamics of Antimicrobials

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Pharmacokinetics is the disposition of drugs in the body (how the body acts on the drug); it incorporates terms such as absorption, bioavailability, distribution, protein binding, metabolism, and elimination. Pharmacodynamics is the interaction between the drug concentration at the site of action over time (drug exposure) and the pharmacologic effect, which, in the case of antimicrobials, is eradication of microorganisms. Pharmacokinetics and pharmacodynamics are interrelated. Both need to be taken into account to optimize antimicrobial therapy.

Chapter.  5081 words.  Illustrated.

Subjects: Infectious Diseases

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