Infections in Transplant Recipients

Raymund R Razonable

in Mayo Clinic Infectious Diseases Board Review

Published on behalf of © Mayo Foundation for Medical Education and Research

Published in print January 2012 | ISBN: 9780199827626
Published online June 2012 | e-ISBN: 9780199929641 | DOI:

Series: Mayo Clinic Scientific Press

Infections in Transplant Recipients

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Infections are the most common complication of organ transplant. They are caused by bacteria, fungi, viruses, and parasites. Transplant-associated infections usually fall into one of several categories: nosocomial or health care–associated pathogens (Staphylococcus aureus, enterococci, Pseudomonas aeruginosa, and others), opportunistic pathogens (cytomegalovirus, Aspergillus fumigatus, Pneumocystis jiroveci, polyomaviruses BK virus and JC virus, and others), and community-acquired pathogens (Streptococcus pneumoniae and respiratory viruses). Determinants of risk of infection after transplant include epidemiologic exposures (exposure history for both donor and recipient) and net state of immunosuppression (including antirejection immunosuppressive drugs, graft-vs-host disease prophylaxis and treatment, cytotoxic chemotherapy, immunomodulating viruses, and inherent defects in innate and adaptive immunity). Diagnosis and treatment of various types of infections are reviewed.

Chapter.  6310 words.  Illustrated.

Subjects: Infectious Diseases

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