A New Era for Lesion-Behavior Mapping of Prefrontal Functions

Emmanuelle Volle, Richard Levy and Paul W. Burgess

in Principles of Frontal Lobe Function

Published on behalf of Oxford University Press

Published in print February 2013 | ISBN: 9780199837755
Published online September 2013 | e-ISBN: 9780199353224 | DOI:
A New Era for Lesion-Behavior Mapping of Prefrontal Functions

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Chapter 30 reviews the main steps and difficulties of voxel-based methods for lesion studies. Then possible applications of these methods to prefrontal research will be illustrated in two important domains: the organization of lateral PFC for working memory and the specific roles of the most anterior prefrontal area, rostral PFC, in human cognition, particularly in prospective memory. Working memory have been extensively studied using functional imaging and nonhuman primate studies, yielding conflicting findings and different cognitive models. The second part of this chapter shows how the lesion approach helped to reconcile previous data and to propose a new model of prefrontal organization. In the third part of the chapter, after discussing working memory, it examines prospective memory and the related concept of multitasking, which have until recently hardly been explored in brain neuroimaging.

Chapter.  21870 words.  Illustrated.

Subjects: Neuroscience

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