Pathophysiology of Arterial Thrombosis

Robert D. McBane and Waldemar E. Wysokinski

in Mayo Clinic Cardiology

Fourth edition

Published on behalf of © Mayo Foundation for Medical Education and Research

Published in print November 2012 | ISBN: 9780199915712
Published online May 2013 | e-ISBN: 9780199322824 | DOI:

Series: Mayo Clinic Scientific Press

Pathophysiology of Arterial Thrombosis

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Atherosclerosis is the most common cause of major disability and death in the United States. The most devastating complication of this disease occurs when a platelet-rich thrombus abruptly occludes arterial blood flow, resulting in acute MI, stroke, or sudden cardiac death. This chapter reviews the basic pathophysiology of arterial thrombosis. The pathophysiology of arterial thrombosis involves platelet-rich thrombus formation over a ruptured atherosclerotic plaque. This process can be partitioned into platelet adhesion, coagulation factor activation, and thrombus propagation through platelet accretion.

Chapter.  4119 words.  Illustrated.

Subjects: Cardiovascular Medicine

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