Treatment and Prevention of Arterial Thrombosis

Robert D. McBane and Waldemar E. Wysokinski

in Mayo Clinic Cardiology

Fourth edition

Published on behalf of © Mayo Foundation for Medical Education and Research

Published in print November 2012 | ISBN: 9780199915712
Published online May 2013 | e-ISBN: 9780199322824 | DOI:

Series: Mayo Clinic Scientific Press

Treatment and Prevention of Arterial Thrombosis

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Each year, 1.45 million Americans have a myocardial infarction and 800,000 Americans have a new or recurrent stroke. These events are thrombotic in nature and are therefore potentially treatable and preventable with the appropriate use of antithrombotic agents. Current antithrombotic therapy targets 3 of the 4 stages of thrombus formation: platelet activation, platelet aggregation, and coagulation cascade activation. There are no effective means to prevent the initial stage of platelet adhesion to injured arterial walls. This chapter reviews the mechanism of action, pharmacology, and clinical use of agents for the prevention and treatment of arterial thrombosis.

Chapter.  11746 words.  Illustrated.

Subjects: Cardiovascular Medicine

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