Joseph G. Murphy, Thomas G. Allison and R. Scott Wright

in Mayo Clinic Cardiology

Fourth edition

Published on behalf of © Mayo Foundation for Medical Education and Research

Published in print November 2012 | ISBN: 9780199915712
Published online May 2013 | e-ISBN: 9780199322824 | DOI:

Series: Mayo Clinic Scientific Press


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Abnormal cholesterol and lipoprotein metabolism, together with endothelial injury are the major progenitors of atherosclerosis, the leading cause of obstructive coronary artery and vascular diseases worldwide. Dyslipidemia in particular is considered an essential risk factor because atherosclerotic plaques are formed in large part from cholesterol. Low-density lipoprotein (LDL) is a heterogenous collection of lipoproteins and can be separated into subtypes of different size and density. However, not all LDL particles have the same atherosclerotic potential. High-density lipoprotein (HDL) in the blood exists in small, intermediate, and large-sized particles, designations which reflect their cholesterol content. A large body of epidemiological data certainly suggests an inverse relationship between HDL levels in populations and risk of coronary heart disease, and that this risk is independent of LDL cholesterol.

Chapter.  5300 words.  Illustrated.

Subjects: Cardiovascular Medicine

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