Diabetes Mellitus and Coronary Artery Disease

Robert L. Frye and David R. Holmes

in Mayo Clinic Cardiology

Fourth edition

Published on behalf of © Mayo Foundation for Medical Education and Research

Published in print November 2012 | ISBN: 9780199915712
Published online May 2013 | e-ISBN: 9780199322824 | DOI:

Series: Mayo Clinic Scientific Press

Diabetes Mellitus and Coronary Artery Disease

Show Summary Details


The prevalence of diabetes mellitus has reached epidemic proportions and continues to increase. Type 2 diabetes has been estimated to account for up to 90% to 95% of all diagnosed cases of diabetes. Heart disease is the leading cause of diabetes-related mortality. Almost two-thirds of diabetics die of heart or blood vessel disease, and death rates from heart disease are two to four times higher among diabetic patients than among nondiabetic patients. In addition, diabetes is associated with an increase in the risk of stroke. Cardiologists need to understand that fat cells (adipocytes) are active metabolically and are the source of several cytokines and other substances that not only influence insulin sensitivity and resistance but have profound effects on the cardiovascular system.

Chapter.  2780 words.  Illustrated.

Subjects: Cardiovascular Medicine

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