Systolic Heart Function

Wayne L. Miller and Lyle J. Olson

in Mayo Clinic Cardiology

Fourth edition

Published on behalf of © Mayo Foundation for Medical Education and Research

Published in print November 2012 | ISBN: 9780199915712
Published online May 2013 | e-ISBN: 9780199322824 | DOI:

Series: Mayo Clinic Scientific Press

Systolic Heart Function

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The myocardium is composed of cardiac myocytes enveloped in a dense extracellular matrix of collagen, the main structural protein of the heart. The coupling of cardiac excitation (an electrical event) and contraction (a mechanical event) is fundamentally molecular. Relaxation is brought about by the active reuptake of calcium into the sarcoplasmic reticulum. Thus, calcium is essential to the excitation-contraction coupling, and when the calcium concentration decreases to a critical point, contraction ceases. These heart functions, their mechanical determinants (ie, preload, afterload, contractility, and heart rate), and physiologic measures of left ventricular systolic function are reviewed in this chapter.

Chapter.  3409 words.  Illustrated.

Subjects: Cardiovascular Medicine

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