Chapter

Hypertrophic Cardiomyopathy

Steve R. Ommen

in Mayo Clinic Cardiology

Fourth edition

Published on behalf of © Mayo Foundation for Medical Education and Research

Published in print November 2012 | ISBN: 9780199915712
Published online May 2013 | e-ISBN: 9780199322824 | DOI: http://dx.doi.org/10.1093/med/9780199915712.003.1883

Series: Mayo Clinic Scientific Press

Hypertrophic Cardiomyopathy

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The clinical definition of hypertrophic cardiomyopathy is left ventricular hypertrophy in the absence of other causes of left ventricular hypertrophy. The size and volume of the left ventricle are usually normal or smaller. Most cases are familial disease with autosomal dominant inheritance. Histologically, loose connective tissue is surrounded by myocyte hypertrophy and disarray. Arrhythmias and systolic left ventricular outflow tract gradients are common, and premature sudden death occurs in approximately 1% of hypertrophic cardiomyopathy patients annually. This chapter reviews the pathogenesis, pathologic and morphologic features, clinical presentation, diagnostic evaluation, and management of hypertrophic cardiomyopathy.

Chapter.  4933 words.  Illustrated.

Subjects: Cardiovascular Medicine

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