Chapter

Functional Connectivity: Application to Developmental Disorders

Luke Bloy, Ragini Verma and Timothy P.L. Roberts

in Neurobiology of Mental Illness

Fourth edition

Published on behalf of Oxford University Press

Published in print July 2013 | ISBN: 9780199934959
Published online November 2013 | e-ISBN: 9780199349036 | DOI: https://dx.doi.org/10.1093/med/9780199934959.003.0075
Functional Connectivity: Application to Developmental Disorders

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Noninvasive imaging and electrophysiological methods have been developed to facilitate the in vivo investigation of brain function and dysfunction. Such methods have been employed, with great success, to the functional mapping of the brain, as well as the characterization of the temporal activity of these regions during a variety of tasks and experimental conditions. These methods are however inadequate to fully capture our current understanding of brain activity, as the complex interplay of structurally and functionally connected networks of neuronal ensembles. Here we offer an overview of the methodological advancements that have been made to better facilitate the investigation of connectivity in the brain and its relationship to development and pathology. We have focused primarily on in vivo modalities that have been most widely adopted, namely fMRI and electro/magneto encephalography for the investigation of functional connectivity and diffusion MRI for structural connectivity. Finally, the application of these methodologies to the study of neurodevelopmental disorders, such as the autism spectrum disorders, schizophrenia and attention deficit hyperactivity disorder, is presented.

Chapter.  12459 words. 

Subjects: Neuroscience

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