Chapter

Parkinson Disease

Thien Thien Lim and Hubert H. Fernandez

in Neurobiology of Disease

Second edition

Published on behalf of Oxford University Press

Published in print August 2016 | ISBN: 9780199937837
Published online March 2017 | e-ISBN: 9780190219093 | DOI: https://dx.doi.org/10.1093/med/9780199937837.003.0003
Parkinson Disease

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Levodopa is the most efficacious medication to reduce motor impairment in Parkinson disease (PD). The effect of levodopa can wear off after time, which is treated by increasing the dose or shortening the inter-dose interval. Dyskinesias can be treated by a change in levodopa dosing or route of administration, such as by constant administration of levodopa as a gel through a jejunostomy tube or a change to dopamine agonists or amantadine. Non-motor signs including depression can be treated with several antidepressants. Surgical treatments including pallidotomy, thalamotomy, and deep brain stimulation (DBS) have emerged as effective therapies in selected patients with PD refractory to drug treatment.

Chapter.  7389 words. 

Subjects: Neurology

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