Journal Article

Excess of Amino Acid Substitutions Relative to Polymorphism Between X-Linked Duplications in <i>Drosophila melanogaster</i>

Kevin Thornton and Manyuan Long

in Molecular Biology and Evolution

Published on behalf of Society for Molecular Biology and Evolution

Volume 22, issue 2, pages 273-284
Published in print February 2005 | ISSN: 0737-4038
Published online October 2004 | e-ISSN: 1537-1719 | DOI: http://dx.doi.org/10.1093/molbev/msi015
Excess of Amino Acid Substitutions Relative to Polymorphism Between X-Linked Duplications in Drosophila melanogaster

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We have obtained sequence polymorphism data from 13 genes belonging to 5 gene families in Drosophila melanogaster where the Ka/Ks between copies is greater than 1. Twelve of these 13 loci are X-linked. In general, there is evidence of purifying selection in all families, as inferred both from levels of silent and replacement variation and insertion/deletion variation, suggesting that the loci are likely functional. Shared polymorphisms indicative of gene conversion between paralogs are rare among the X-linked families, in contrast to available data from autosomal duplicates. McDonald-Kreitman tests between duplicates reveal an excess of amino-acid fixations between copies in the X-linked families, suggesting that the divergence between these loci was driven by positive selection. In contrast, available data from autosomal duplicates show a deficit of fixations, consistent with gene conversion being a strong homogenizing force.

Keywords: Drosophila; gene duplicates; positive selection; pseudogenes; polymorphism; concerted evolution

Journal Article.  8886 words.  Illustrated.

Subjects: Evolutionary Biology ; Molecular and Cell Biology

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