Journal Article

Recurrent Positive Selection of the Drosophila Hybrid Incompatibility Gene <i>Hmr</i>

Shamoni Maheshwari, Jun Wang and Daniel A. Barbash

in Molecular Biology and Evolution

Published on behalf of Society for Molecular Biology and Evolution

Volume 25, issue 11, pages 2421-2430
Published in print November 2008 | ISSN: 0737-4038
Published online August 2008 | e-ISSN: 1537-1719 | DOI: https://dx.doi.org/10.1093/molbev/msn190
Recurrent Positive Selection of the Drosophila Hybrid Incompatibility Gene Hmr

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Lethality in hybrids between Drosophila melanogaster and its sibling species Drosophila simulans is caused in part by the interaction of the genes Hybrid male rescue (Hmr) and Lethal hybrid rescue (Lhr). Hmr and Lhr have diverged under positive selection in the hybridizing species. Here we test whether positive selection of Hmr is confined only to D. melanogaster and D. simulans. We find that Hmr has continued to diverge under recurrent positive selection between the sibling species D. simulans and Drosophila mauritiana and along the lineage leading to the melanogaster subgroup species pair Drosophila yakuba and Drosophila santomea. Hmr encodes a member of the Myb/SANT-like domain in ADF1 (MADF) family of transcriptional regulators. We show that although MADF domains from other Drosophila proteins have predicted ionic properties consistent with DNA binding, the MADF domains encoded by different Hmr orthologs have divergent properties consistent with binding to either the DNA or the protein components of chromatin. Our results suggest that Hmr may be functionally diverged in multiple species.

Keywords: adaptive evolution; hybrid incompatibility; speciation; MADF domain; positive selection

Journal Article.  6616 words.  Illustrated.

Subjects: Evolutionary Biology ; Molecular and Cell Biology

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