Journal Article

SURVEY AND SUMMARY: <i>Saccharomyces cerevisiae</i> basic helix–loop–helix proteins regulate diverse biological processes

Kelly A. Robinson and John M. Lopes

in Nucleic Acids Research

Volume 28, issue 7, pages 1499-1505
Published in print April 2000 | ISSN: 0305-1048
Published online April 2000 | e-ISSN: 1362-4962 | DOI: http://dx.doi.org/10.1093/nar/28.7.1499
SURVEY AND SUMMARY: Saccharomyces cerevisiae basic helix–loop–helix proteins regulate diverse biological processes

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Basic helix–loop–helix (bHLH) proteins are among the most well studied and functionally important regulatory proteins in all eukaryotes. The HLH domain dictates dimerization to create homo- and heterodimers. Dimerization juxtaposes the basic regions of the two monomers to create a DNA interaction surface that recognizes the consensus sequence called the E-box, 5′-CANNTG-3′. Several bHLH proteins have been identified in the yeast Saccharomyces cerevisiae using traditional genetic methodologies. These proteins regulate diverse biological pathways. The completed sequence of the yeast genome, combined with novel methodologies allowing whole-genome expression studies, now offers a unique opportunity to study the function of these bHLH proteins. It is the purpose of this review to summarize the current knowledge of bHLH protein function in yeast.

Journal Article.  5537 words.  Illustrated.

Subjects: Chemistry ; Biochemistry ; Bioinformatics and Computational Biology ; Genetics and Genomics ; Molecular and Cell Biology

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