Journal Article

A database of immunoglobulins with integrated tools: DIGIT

Anna Chailyan, Anna Tramontano and Paolo Marcatili

in Nucleic Acids Research

Volume 40, issue D1, pages D1230-D1234
Published in print January 2012 | ISSN: 0305-1048
Published online November 2011 | e-ISSN: 1362-4962 | DOI: http://dx.doi.org/10.1093/nar/gkr806

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The DIGIT (Database of ImmunoGlobulins with Integrated Tools) database (http://biocomputing.it/digit) is an integrated resource storing sequences of annotated immunoglobulin variable domains and enriched with tools for searching and analyzing them. The annotations in the database include information on the type of antigen, the respective germline sequences and on pairing information between light and heavy chains. Other annotations, such as the identification of the complementarity determining regions, assignment of their structural class and identification of mutations with respect to the germline, are computed on the fly and can also be obtained for user-submitted sequences. The system allows customized BLAST searches and automatic building of 3D models of the domains to be performed.

Journal Article.  2668 words.  Illustrated.

Subjects: Chemistry ; Biochemistry ; Bioinformatics and Computational Biology ; Genetics and Genomics ; Molecular and Cell Biology

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