Journal Article

Efficient liquid-phase synthesis of short-length nucleotides <i>via</i> the phosphoramidite method using stoichiometric amounts of reactants

Akiyoshi Hirata, Jun-ichiro Sugimoto, Rie Kawai, Masanori Kataoka and Yoshihiro Hayakawa

in Nucleic Acids Symposium Series

Volume 1, issue 1, pages 215-216
Published in print November 2001 | ISSN: 0261-3166
Published online November 2001 | e-ISSN: 1746-8272 | DOI: http://dx.doi.org/10.1093/nass/1.1.215
Efficient liquid-phase synthesis of short-length nucleotides via the phosphoramidite method using stoichiometric amounts of reactants

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The condensation of a nucleoside phosphoramidite and a nucleoside by the aid of a suitable promoter in stoichiometric use is achieved in acetonitrile in the presence of molecular sieves 3A or 4A to give a desired coupling product in an excellent yield. This strategy is particularly useful for the large-scale synthesis of short nucleotides.

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Subjects: Chemistry ; Bioinformatics and Computational Biology ; Genetics and Genomics ; Molecular and Cell Biology

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