Journal Article

Tandem oligonucleotide synthesis using linker (First Base™) phosphoramidites

Richard T. Pon and Shuyuan Yu

in Nucleic Acids Symposium Series

Volume 2, issue 1, pages 1-2
Published in print November 2002 | ISSN: 0261-3166
Published online November 2002 | e-ISSN: 1746-8272 | DOI: http://dx.doi.org/10.1093/nass/2.1.1
Tandem oligonucleotide synthesis using linker (First Base™) phosphoramidites

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First Base™ linker phosphoramidites add the first nucleoside to underivatized solid-phase supports using a regular phosphoramidite coupling cycle. A cleavable 3′-O-ester linkage allows NH4OH treatment to rapidly generate products with only 3′-OH ends. Either single or multiple sequences linked in tandem can be prepared and no additional deprotection steps are required.

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Subjects: Chemistry ; Bioinformatics and Computational Biology ; Genetics and Genomics ; Molecular and Cell Biology

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