Journal Article

Repair of oxidative cytosine damage by DNA glycosylases

Atsushi Katafuchi, Aya Matsuo, Hiroaki Terato, Yoshihiko Ohyama and Hiroshi Ide

in Nucleic Acids Symposium Series

Volume 3, issue 1, pages 269-270
Published in print September 2003 | ISSN: 0261-3166
Published online September 2003 | e-ISSN: 1746-8272 | DOI: https://dx.doi.org/10.1093/nass/3.1.269
Repair of oxidative cytosine damage by DNA glycosylases

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5-Hydroxyuracil (HOU) and 5-hydroxycytosine (HOC) are major oxidative lesions of cytosine with mutagenic potentials. Therefore, HOU and HOC need to be removed from DNA to avoid mutation. In this study, oligonucleotide substrates containing HOU and HOC were synthesized by DNA polymerase reactions and tested for DNA glycosylases. Ung exhibited an extremely low activity for HOU as compared to uracil (U). In contrast, hSMUG1 excised HOU and U with a comparable efficiency. Ung and hSMUG1 did not excise HOC.

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Subjects: Chemistry ; Bioinformatics and Computational Biology ; Genetics and Genomics ; Molecular and Cell Biology

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