Journal Article

Photoinduced excess electron injection into DNA duplexes containing mismatched base pairs

Takeo Ito, Akiko Kondo, Aiko Hayashi, Tsukasa Uchida, Kazuhito Tanabe and Sei-ichi Nishimoto

in Nucleic Acids Symposium Series

Volume 52, issue 1, pages 421-422
Published in print September 2008 | ISSN: 0261-3166
Published online September 2008 | e-ISSN: 1746-8272 | DOI: http://dx.doi.org/10.1093/nass/nrn214
Photoinduced excess electron injection into DNA duplexes containing mismatched base pairs

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A series of DNA containing photoinduced electron donors and mismatched DNA base pairs have been prepared and applied for the chemical investigation of excess electron transfer (EET) in the duplex DNA. As the electron donors, phenothiazine (PTZ) with a flexible linker was tethered to the 5′-end or in the middle of the sequences, or diaminostilbene (DAS) was covalently linked to form a hairpin structure. The presence of mismatched base pair lowered EET efficiency in the DAS-capped DNA hairpins, on the other hand, efficient EET beyond the mismatch site was observed in the PTZ-conjugated DNA.

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Subjects: Chemistry ; Bioinformatics and Computational Biology ; Genetics and Genomics ; Molecular and Cell Biology

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