Journal Article

Epidemiology of HCV infection: disease and renal transplantation

J. M. Cisterne, L. Rostaing, J. Izopet, M. H. Chabannier, E. Baron, M. Duffaut, D. Durand and J. M. Suc

in Nephrology Dialysis Transplantation

Volume 11, issue supp4, pages 46-47
Published in print January 1996 | ISSN: 0931-0509
Published online January 1996 | e-ISSN: 1460-2385 | DOI:
Epidemiology of HCV infection: disease and renal transplantation

Show Summary Details


We studied the prevalence of HCV infection in a cohort of 346 patients who received renal transplantation between January 1989 and April 1994. Assessments were made at the time of surgery, one year later and at the last follow-up visit. The hepatic consequences of HCV infection were also studied. The prevalence of HCV infection at the time of surgery was 21.4% (74/346). The risk factors associated with the presence of anti-HCV antibodies were: duration of haemodialysis, the number of transfusions and the number of previous renal transplantations. The incidence of HCV infection was 3% (8/272) and was accompained by either transient (n=4) or chronic (n=3) hepatic cytolysis; five patients underwent liver biopsy which revealed persistent chronic hepatitis (n=2) or active chronic hepatitis (n=3). Seroconversion always occurred within one year following transplantation. In the long-term, 91% of HCV + patients remained viraemic. The HCV genotype was predominantly 1b. Fiftysix percent (56%) of HCV + patients had normal ALAT at the time of transplantation, which remained normal on follow-up in two-thirds of cases. After transplantation, 39 HCV + patients underwent liver biopsy. ALAT were normal in 13 of those; liver biopsy elicited either normal liver (n=1) or chronic persistent hepatitis (CPH) (n=8) or chronic active hepatitis (CAH) (n=4). ALAT were chronically elevated in 26 patients; liver histology revealed: 7 CPH, 19 CAH including 12 cases with bridging fibrosis. No deleterious effect of azathioprine on liver histology was found. Lastly, four patients were co-infected with HBV: all had elevated ALAT; liver biopsy always revealed severe chronic active hepatitis. Post-transplantation hepatitis C is a worrying problem. Liver enzymes are not correlated with the severity of histological disorders, which are frequent. Interferon-α therapy should be proposed to HCV + patients before renal transplantation.

Journal Article.  0 words. 

Subjects: Nephrology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.