Journal Article

Glomerular disease during HCV infection in renal transplantation

H. Hammoud, J. Haem, B. Laurent, E. Alamartine, N. Diab, J. P. Defilippis, P. Berthoux and F. Berthoux

in Nephrology Dialysis Transplantation

Volume 11, issue supp4, pages 54-55
Published in print January 1996 | ISSN: 0931-0509
Published online January 1996 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/11.supp4.54
Glomerular disease during HCV infection in renal transplantation

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In general nephrology, HCV infection has been associated with type I membranoproliferative glomeruionephritis (MPGN type I) associated with cryoglobulinaemia. In a cohort of 399 renal transplantation (RT) recipients, 117 of whom (29%) were HCV-positive, we selected all patients diagnosed as having membranous GN or type I MPGN by graft biopsy. The prevalence of MGN was 16/399 (4%) with three recurrences, and 13 de novo cases. Only 5/16 (31%) were HCV+, not different from the general RT population. Five patients had an outcome of graft failure after 43 months. Conversely, there were 15 cases of type I MPGN (two recurrences, 13 de novo) but with eight HCV+ recipients (53%, P=0.02). Considering only the French patients, prevalence was 44% vs 12% in the French RT population (P=0.006). Eight patients had graft rejection after 59 months (five HCV+). In this type I MPGN subgroup, there were two positive cryoglobulins, two rheumatoid factors and four hypocomplementaemias. In conclusion, there is a clear association between HCV infection and the occurrence of type I MPGN in the allograft in renal transplantation, with terminal renal failure as an outcome.

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Subjects: Nephrology

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