Journal Article

Expression of receptors for advanced glycation end-products in occlusive vascular and renal disease

Angelika Bierhaus, Eberhard Ritz and Peter P. Nawroth

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 11, issue supp5, pages 87-90
Published in print January 1996 | ISSN: 0931-0509
e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/11.supp5.87
Expression of receptors for advanced glycation end-products in occlusive vascular and renal disease

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Formation and deposition of advanced glycation end-products (AGEs) has been linked to late diabetic complications. Interactions of AGEs are at least partly mediated by binding of AGEs to their cellular surface receptor RAGE. This review summarizes the immunohistological data obtained for RAGE distribution in vessel segments of diabetic and non-diabetic patients with peripheral occlusive vascular disease and in kidneys of patients with diabetic nephropathy, and inflammatory and non-inflammatory renal disease. It is demonstrated that increased RAGE expression is not restricted to diabetes mellitus but contributes to a range of vascular and renal disorders.

Keywords: AGE; diabetes; endothelium; occlusive vascular disease; RAGE; renal disease

Journal Article.  0 words. 

Subjects: Nephrology

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