Journal Article

Pharmacokinetics of carboplatin and etoposide in a haemodialysis patient with Merkel-cell carcinoma.

S Suzuki, M Koide, S Sakamoto and T Matsuo

in Nephrology Dialysis Transplantation

Volume 12, issue 1, pages 137-140
Published in print January 1997 | ISSN: 0931-0509
Published online January 1997 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/12.1.137
Pharmacokinetics of carboplatin and etoposide in a haemodialysis patient with Merkel-cell carcinoma.

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We present a Merkel-cell carcinoma patient with chronic renal failure requiring haemodialysis and evaluate the pharmacokinetics of carboplatin and etoposide during haemodialysis. The area under the concentration-time curve of carboplatin was increased by prolonging the interval between administration and haemodialysis. However, that of etoposide was not changed. Carboplatin showed good membrane permeability in haemodialysis, while etoposide showed no permeability. In conclusion, the pharmacokinetics of carboplatin could be controlled by haemodialysis and the interval between chemotherapy and haemodialysis. However, the pharmacokinetics of etoposide were not affected.

Journal Article.  0 words. 

Subjects: Nephrology

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