Journal Article

TGF-beta and glomerulonephritis: anti-inflammatory versus prosclerotic actions.

M Kitamura and T S Sütö

in Nephrology Dialysis Transplantation

Volume 12, issue 4, pages 669-679
Published in print April 1997 | ISSN: 0931-0509
Published online April 1997 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/12.4.669
TGF-beta and glomerulonephritis: anti-inflammatory versus prosclerotic actions.

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TGF-beta has been considered as the key regulator in the generation of glomerulosclerosis. Despite abundant descriptive data, it still remains undetermined whether sustained, local expression of TGF-beta leads to irreversible glomerulosclerosis. There is no doubt that TGF-beta stimulates ECM production in the glomerulus, but this molecule has several anti-inflammatory properties as well. Towards a better understanding of the pathogenesis of glomerulonephritis and for the development of novel and efficient therapeutic interventions, extensive efforts should be made to clarify the 'bright side' of TGF-beta as well as its 'dark side' in individual experimental and human diseases, focusing especially on the concentration and the time-point at which its anti-inflammatory properties spill over into its prosclerotic actions.

Journal Article.  0 words. 

Subjects: Nephrology

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