Journal Article

Effect of different membranes on amino-acid losses during haemodialysis

Juan F. Navarro, Roberto Mareén, José L. Teruel, Rafael Martín del Río, Carmen Gámez, Carmen Mora and Joaquin Ortuño

in Nephrology Dialysis Transplantation

Volume 13, issue 1, pages 113-117
Published in print January 1998 | ISSN: 0931-0509
Published online January 1998 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/13.1.113
Effect of different membranes on amino-acid losses during haemodialysis

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Background. We analysed amino-acid losses during haemodialysis, their influence on plasma amino-acid concentration, and their possible effects on nutritional state.

Methods. Five patients were dialysed with three membranes: cuprophan (CUP), polysulphone (PS), and polyacrylonitrile AN69 (PAN). We compared anthropometric and biochemical parameters after 6 months in patients dialysed with CUP respect to patients with PAN.

Results. Total losses of amino acids were higher with PAN than with PS and CUP (6.1 ± 2.3 vs 3.8 ± 1.3, P < 0.05, and 3.7 ± 1.3 g/session, P < 0.01 respectively). Losses of essential amino acids (EAA) and nonessential amino acids (NEAA) were also higher with PAN respect to PS and CUP (1.8 ± 0.8 vs 1 ±0.3 and 0.8 ± 0.3, and 4.3 ± 1.6 vs 2.8 ± 1 and 2.9 ± 1.1 g/session, P < 0.05). The percentage reduction for plasma EAA and NEAA were lower with CUP respect to PS and PAN (11 ± 5% and 20 ± 14% vs 25 ± 10% and 33 ± 11%, and 30 ± 11% and 25 ± 17% respectively, P < 0.05). There was no difference in the nutritional state between patients with CUP and PAN. However, plasma valine in patients with PAN was lower than in those with CUP (1.88 ± 0.12 vs 2.13 ± 0.32 mg/dl) and almost reached statistical significance.

Conclusions. New synthetic membranes are advantageous with respect to conventional ones, but a disadvantage is the higher amino-acid losses, especially with polyacrylonitrile. Long-term studies are necessary to evaluate the impact of amino-acid losses on nutritional state in patients dialysed with these membranes.

Keywords: amino acid losses; haemodialysis; dialysis membrane; biocompatibility; nutritional state

Journal Article.  0 words. 

Subjects: Nephrology

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