Journal Article

Severe experimental uraemia does not decrease the population of rat pituitary somatotrophs.

J Rodríguez, E Carbajo-Pérez, F Santos, S Carbajo, N Fernández, P Fernández, M Fernández and E García

in Nephrology Dialysis Transplantation

Volume 13, issue 10, pages 2563-2565
Published in print October 1998 | ISSN: 0931-0509
Published online October 1998 | e-ISSN: 1460-2385 | DOI:
Severe experimental uraemia does not decrease the population of rat pituitary somatotrophs.

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BACKGROUND: Growth hormone (GH) secretion by the anterior pituitary has been shown to be depressed in severely uraemic rats. Changes in the population of pituitary somatotrophs might be partially responsible for this decrease. METHODS: To analyse the population of pituitary somatotrophs in severe uraemia, immunocytochemical detection and quantification of GH-producing cells were carried out on paraffin sections from young rats either 5/6 nephrectomized, sham-operated fed ad libitum or sham-operated pair-fed with the nephrectomized animals. Results: Nephrectomized rats were severely uraemic and growth retarded. The overall cell density (total pituitary cells/mm2) was higher in 5/6 nephrectomized animals in comparison with the two sham-operated groups. Thus, although the percentage of GH cells was slightly lower in nephrectomized than in control rats, no difference in either the density (cells/mm2) or the cross-sectional area of GH cells was found among groups. CONCLUSIONS: These results suggest that severe experimental uraemia interferes with the maturation process of the pituitary gland and support the contention that differences in either the number or the size of pituitary somatotrophs cannot explain the reduced GH secretion previously reported in severely uraemic rats.

Journal Article.  0 words. 

Subjects: Nephrology

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