Journal Article

Functional correlates of <i>α</i><sub>2A</sub>-adrenoceptor gene polymorphism in the HANE study

Martin C. Michel, Christopher Plogmann, Thomas Philipp and Otto-Erich Brodde

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 14, issue 11, pages 2657-2663
Published in print November 1999 | ISSN: 0931-0509
Published online November 1999 | e-ISSN: 1460-2385 | DOI:
Functional correlates of α2A-adrenoceptor gene polymorphism in the HANE study

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Background. The aim of this study was to test an association between alleles of the α2A-adrenoceptor gene with hereditary hypertension and with alterations of lipid and carbohydrate metabolism.

Methods. Genomic DNA was isolated from 147 hypertensive patients and digested with DraI. Genotypes at the α2A-adrenoceptor were identified by restriction fragment length polymorphism. Genotype at each locus was related to blood pressure, family history of hypertension and various clinical chemistry parameters.

Results. The α2A-adrenoceptor polymorphism was not significantly associated with blood pressure or a family history of hypertension. Patients with the d allele of the α2A-adrenoceptor had significantly lower HbA1 (5.6 vs 6.2%, P=0.0344) and HbA1c (3.4 vs 3.9%, P=0.0237) and total cholesterol (212 vs 229 mg/dl, P=0.0333) than those without. Similar trends, which failed to reach statistical significance, were seen for glucose, triglycerides and LDL cholesterol.

Conclusions. We propose that alleles at the α2A-adrenoceptor locus might contribute to interindividual differences in the regulation of human lipid and glucose metabolism.

Keywords: α2A-adrenoceptor; cholesterol; gene polymorphism; HbA1

Journal Article.  4903 words.  Illustrated.

Subjects: Nephrology

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