Journal Article

Disturbed LDL and scavenger receptor functions in monocytes from chronic haemodialysed patients

István Kárpáti, György Paragh, Éva Kovács, Zoltán Balogh, Márton Szabolcs, Jenõ Szabó, György Kakuk and Gabriella Fóris

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 14, issue 11, pages 2664-2668
Published in print November 1999 | ISSN: 0931-0509
Published online November 1999 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/14.11.2664
Disturbed LDL and scavenger receptor functions in monocytes from chronic haemodialysed patients

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Background. The most frequent complication in patients with end-stage renal failure on chronic haemodialysis (HD) treatment is atherosclerosis, i.e. the different forms of heart and vascular diseases. The complete disorder of serum lipid and lipoprotein patterns is well demonstrated, whereas our knowledge about the low-density lipoprotein (LDL) and scavenger receptor expression and function are poorly understood.

Methods. In our current work, LDL and scavenger receptor expression and functions were simultaneously studied in monocytes obtained from 15 healthy male control subjects and from 11 chronic HD male patients applied with 125I-labelled LDL, isolated from healthy volunteers. To study the scavenger LDL receptors, labelled acetylated LDL (acLDL) was used.

Results. LDL binding to the monocytes of the HD-group was found to be decreased in comparison to that of the controls. As a result, the 50 μg LDL protein-induced inhibition of endogenous cholesterol synthesis was also diminished. In contrast, acLDL binding was greatly increased, though it could trigger only a low apoE synthesis. Consequently the number of cholesterol inclusions in monocytes was increased.

Conclusions. The disturbed expression and function of LDL and scavenger receptors both may play significant roles in pathogenesis of cardiovascular complications in chronic HD patients. Based on our present results, it can be assumed that dysfunction of scavenger receptors is at the centre of cardiovascular complications of HD patients with renal failure.

Keywords: cholesterol synthesis; foam cell; haemodialysis; LDL receptor; monocyte; scavenger receptor

Journal Article.  3372 words.  Illustrated.

Subjects: Nephrology

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