Journal Article

Recent insights into the structure and functions of heparan sulfate proteoglycans in the human glomerular basement membrane

Alexander J. A. Groffen, Jacques H. Veerkamp, Leo A. H. Monnens and Lambert P. W. J. van den Heuvel

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 14, issue 9, pages 2119-2129
Published in print September 1999 | ISSN: 0931-0509
Published online September 1999 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/14.9.2119
Recent insights into the structure and functions of heparan sulfate proteoglycans in the human glomerular basement membrane

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As the first barrier to be crossed on the way to urinary space, the glomerular basement membrane (GBM) plays a key role in renal function. The permeability of the GBM for a given molecule is highly dependent on its size, shape and charge. As early as 1980, the charge-selective permeability was demonstrated to relate to the electrostatic properties of covalently bound heparan sulfates (HS) within the GBM. Since the identification of perlecan as a heparan sulfate proteoglycan (HSPG) of basement membranes, the hypothesis that perlecan could be a crucial determinant of GBM permselectivity received considerable attention. In addition to perlecan, the GBM also contains other HSPG species, one of which was identified as agrin. The high local expression of agrin in the GBM, together with the presence of agrin receptors at the cell–matrix interface, suggests that this HSPG contributes to glomerular function in multiple ways. Here, we review the current knowledge regarding the structure and functions of HSPGs in the GBM, and discuss how these molecules could be involved in various glomerular diseases. Possible directions for future investigation are suggested.

Journal Article.  8485 words.  Illustrated.

Subjects: Nephrology

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