Journal Article

Expression of bcl-2 and bax in glomerular disease.

A Yoshimura, S Uda, K Inui, T Nemoto, Y Sugenoya, S Sharif, N Yokota, S Watanabe and T Ideura

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 14, issue suppl_1, pages 55-57
Published in print January 1999 | ISSN: 0931-0509
Published online January 1999 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/14.suppl_1.55
Expression of bcl-2 and bax in glomerular disease.

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Bcl-2 may account in part for the maintenance of hypercellularity in human glomerular diseases through preventing cell death and by counteracting bax which may be expressed to regulate excessive proliferation. This process is associated with the effect of PDGF B-chain expression. Bax expression may be important in the cell loss leading to glomerulosclerosis and TGF-beta1 participates in this process by increasing bax expression. Thus, the balance of bcl-2/bax expression may be critical in the course of human glomerular diseases.

Journal Article.  0 words. 

Subjects: Nephrology

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