Journal Article

Regulation of PiT-1, a sodium-dependent phosphate co-transporter in rat parathyroid glands.

K Miyamoto, S Tatsumi, H Segawa, K Morita, T Nii, A Fujioka, M Kitano, Y Inoue and E Takeda

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 14, issue suppl_1, pages 73-75
Published in print January 1999 | ISSN: 0931-0509
Published online January 1999 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/14.suppl_1.73
Regulation of PiT-1, a sodium-dependent phosphate co-transporter in rat parathyroid glands.

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A cDNA encoding an Na+-Pi co-transporter, termed rat PiT-1, has now been isolated from rat parathyroid. Expression of rat PiT-1 in Xenopus oocytes revealed that it possesses Na+-dependent Pi co-transport activity. The amount of PiT-1 mRNA in the parathyroid of vitamin D-deficient rats was reduced compared with that in normal animals, and increased markedly after administration of 1,25-dihydroxyvitamin D3. Furthermore, the abundance of PiT-1 mRNA in the parathyroid was much greater in rats fed a low-Pi diet than in those fed a high-Pi diet. Thus, rat PiT-1 may contribute to the effects of Pi and vitamin D on parathyroid function.

Journal Article.  0 words. 

Subjects: Nephrology

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