Journal Article

Age‐matching in renal transplantation

Johannes Waiser, Matthias Schreiber, Klemens Budde, Lutz Fritsche, Torsten Böhler, Ingeborg Hauser and Hans‐H. Neumayer

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 15, issue 5, pages 696-700
Published in print May 2000 | ISSN: 0931-0509
Published online May 2000 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/15.5.696
Age‐matching in renal transplantation

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Background. So far, the combined influence of donor age and recipient age on renal allograft survival has not been investigated sufficiently. In this retrospective single‐centre study we analysed whether the influence of donor age and recipient age on renal allograft survival are dependent on each other.

Methods. Data from 1269 cadaveric renal allograft transplantations were evaluated. Paediatric donors (<15 years) and paediatric recipients (<15 years) were excluded. Donors and recipients were divided by age: young donors (yd, ≤55 years, n=1093), old donors (od, >55 years, n=176), young recipients (yr, ≤55 years, n=1058), and old recipients (or, >55 years, n=211). Functional and actual long‐term graft survival (8 years) within the four resulting groups was determined: yd/yr (n=926), yd/or (n=167), od/yr (n=132), and od/or (n=44).

Results. Univariate analysis showed that long‐term graft survival of both, kidneys from young donors (functional, 66.1 vs 52.2%, P=0.004; actual, 53.3 vs 46.2%, P=0.065) and kidneys from old donors (functional, 68.7 vs 22.5%, P=0.07; actual, 57.1 vs 20.8%, P=0.15) was better in old recipients as compared to young recipients. Multivariate regression analysis revealed that actual graft survival of kidneys from old donors was significantly reduced in young recipients (od/yr) as compared to all other groups (P=0.001; RR, 1.97; 95% CI, 1.32–2.94). In this group of patients, graft loss was mainly due to acute (33.7%) and chronic (24.0%) rejection.

Conclusion. Transplantation of kidneys from ‘old’ donors into ‘young’ recipients should be avoided, and these kidneys should be given to age‐matched recipients.

Keywords: age‐matching; graft survival; renal transplantation

Journal Article.  3251 words.  Illustrated.

Subjects: Nephrology

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