Journal Article

Effects of icodextrin in automated peritoneal dialysis on blood pressure and bioelectrical impedance analysis

Graham Woodrow, Brian Oldroyd, Gillian Stables, Jill Gibson, John H. Turney and Aleck M. Brownjohn

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 15, issue 6, pages 862-866
Published in print June 2000 | ISSN: 0931-0509
Published online June 2000 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/15.6.862
Effects of icodextrin in automated peritoneal dialysis on blood pressure and bioelectrical impedance analysis

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Background. Glucose absorption from glucose‐based dialysis fluids limits ultrafiltration from the daytime dwell in automated peritoneal dialysis (APD). Icodextrin may allow greater ultrafiltration during the daytime period in APD, enhancing fluid control.

Methods. A 7.5% icodextrin dialysate was compared with a 2.27% glucose dialysate for the daytime dwell in 14 subjects on APD. Blood pressure, weight and body water compartments estimated by multifrequency bioelectrical impedance (MFBIA) were determined in subjects using 2.27% glucose as the daytime dwell and then repeated 1 month after switching to icodextrin.

Results. Icodextrin resulted in symptomatic hypotension requiring reduction of antihypertensive medication in six of the 14 patients. Despite this reduction in treatment, systolic blood pressure fell from 142.4 (23.9) mmHg to 122.9 (17.7) mmHg, P<0.005, and diastolic blood pressure tended to fall from 82.8 (9.8) mmHg to 76.8 (10.1) mmHg, P=0.075. Change in systolic blood pressure significantly correlated with changes in weight (r=0.62, P<0.05) and MFBIA estimates of total body water (TBW) (r=0.56, P<0.05), extracellular water (ECW) (r=0.79, P<0.002), extra/intracellular water ratio (ECW/ICW) (r=0.72, P<0.01) and derived resistances Recf of ECW (r=−0.69, P<0.01) and Rinf of TBW (r=−0.66, P<0.02). Changes in diastolic blood pressure significantly correlated with changes in ECW (r=0.64, P<0.02) and ECW/ICW ratio (r=0.58, P<0.05), and almost significantly with Recf (r=−0.51, P=0.08) and Rinf (r=−0.52, P=0.07) estimated by MFBIA, but not with changes in weight or TBW.

Conclusions. Use of icodextrin for the daytime dwell in APD results in improved fluid balance and blood pressure control compared with 2.27% glucose. MFBIA detected clinically important changes in fluid content in these patients.

Keywords: automated peritoneal dialysis; bioelectrical impedance; body water; hypertension; icodextrin; ultrafiltration

Journal Article.  3534 words.  Illustrated.

Subjects: Nephrology

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