Journal Article

Increased blood levels of platelet‐activating factor in insulin‐dependent diabetic patients with microalbuminuria

Paolo Cavallo‐Perin, Enrico Lupia, Gabriella Gruden, Carla Olivetti, Antonella De Martino, Maurizio Cassader, Daniela Furlani, Luigi Servillo, Lucro Quagliuolo, Eugenio Iorio, Marcia Rosario Boccellino, Guiseppe Montrucchio and Giovanni Camussi

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 15, issue 7, pages 994-999
Published in print July 2000 | ISSN: 0931-0509
Published online July 2000 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/15.7.994
Increased blood levels of platelet‐activating factor in insulin‐dependent diabetic patients with microalbuminuria

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Background. Platelet‐activating factor (PAF), a phospholipid mediator of inflammation, may induce an enhanced size‐ and charge‐dependent glomerular permeability in experimental animals. Studies on the role of PAF in enhanced glomerular permeability in the early phase of diabetic nephropathy are still lacking.

Methods. We evaluated the intravascular levels of PAF and its main catabolic enzyme, the PAF‐specific plasma acetyl‐hydrolase (PAF‐AH), in basal conditions and after exercise, in normo‐ or micro‐albuminuric insulin‐dependent diabetic (IDD) patients and in normal subjects.

Results. The results obtained indicate that the concentration of PAF in whole blood was significantly enhanced in basal conditions, during and after exercise in all microalbuminuric IDD patients, but not in normoalbuminuric IDD or in control subjects. The increased concentration of PAF did not correlate with changes in the activity of PAF‐AH, suggesting an enhanced production rather than a decreased catabolism of PAF.

Conclusions. These results indicate an association between increased production of PAF and enhanced glomerular permeability in microalbuminuric IDD patients.

Keywords: PAF; diabetes; microalbuminuria; exercise

Journal Article.  3728 words.  Illustrated.

Subjects: Nephrology

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