Journal Article

The effect of HLA‐C matching on acute renal transplant rejection

Christoph Frohn, Lutz Fricke, Jan‐Christoph Puchta and Holger Kirchner

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 16, issue 2, pages 355-360
Published in print February 2001 | ISSN: 0931-0509
Published online February 2001 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/16.2.355
The effect of HLA‐C matching on acute renal transplant rejection

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Background. The acute immunological rejection and long time survival of kidney allografts are correlated with the human leukocyte antigen (HLA) match status between donor and recipient. HLA‐A, ‐B and ‐DR have all turned out to be relevant HLA loci in several studies. The role of HLA‐C has not been studied before now.

Methods. In 104 consecutive patient/donor pairs from our transplantation unit, we retrospectively analysed whether acute graft rejection is influenced by HLA‐C match status between donor and recipient. For typing HLA‐C alleles, we used an allele‐specific PCR protocol in combination with serology.

Results. By analysing groups of donor/recipient pairs with a homogenous distribution of HLA‐B mismatches in order to exclude an effect of the linkage disequilibrium between HLA‐B/C, HLA‐C mismatch turned out to be significantly correlated with acute transplant rejection in pairs with one additional mismatch on the B locus (P=0.004). Additional parameters that may hypothetically influence acute rejection episodes (HLA‐A or DR mismatch, time of cold and warm ischaemia, previous transplantations, pre‐existing HLA antibodies) were also analysed but cannot explain this finding.

Conclusion. HLA‐C matching of all kidney donors and recipients seems to be an option to reduce the probability of acute rejection episodes. Further studies of greater patient cohorts analysing organ rejection and organ survival are warranted.

Keywords: graft rejection; HLA‐C matching; kidney transplantation; transplantation immunology

Journal Article.  3571 words.  Illustrated.

Subjects: Nephrology

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