Journal Article

HLA‐specific alloantibodies and renal graft outcome

Suchitra Sumitran‐Holgersson

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 16, issue 5, pages 897-904
Published in print May 2001 | ISSN: 0931-0509
Published online May 2001 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/16.5.897
HLA‐specific alloantibodies and renal graft outcome

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HLA‐specific humoral immunity, as a result of recipient allosensitization, induces hyperacute rejection of allogenic kidney grafts. Cross‐match tests are performed to avoid this complication. However, current techniques do not allow determination of HLA‐specificity of donor‐reactive antibodies in the acute cadaver‐donor situation. New methods are described and discussed in this report as well as the alloantibody specificities that are of clinical importance. Alloantibodies not only mediate hyperacute rejection but may also participate in the acute rejection of organ grafts. Clinical associations between early immunological complications, such as acute rejection, in heart, liver and kidney allografted patients and pre‐transplantation humoral alloimmunity emphasize the need for proper determination of donor‐specific humoral immunity prior to transplantation.

Journal Article.  5345 words.  Illustrated.

Subjects: Nephrology

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