Journal Article

Diabetic microvascular complications are not associated with two polymorphisms in the GLUT‐1 and PC‐1 genes regulating glucose metabolism in Caucasian type 1 diabetic patients

Lise Tarnow, Niels Grarup, Torben Hansen, Hans‐Henrik Parving and Oluf Pedersen

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 16, issue 8, pages 1653-1656
Published in print August 2001 | ISSN: 0931-0509
Published online August 2001 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/16.8.1653
Diabetic microvascular complications are not associated with two polymorphisms in the GLUT‐1 and PC‐1 genes regulating glucose metabolism in Caucasian type 1 diabetic patients

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Background. An XbaI polymorphism in the gene encoding the glucose transporter, GLUT‐1, is associated with development of diabetic nephropathy in Chinese type 2 diabetic patients. In addition, an amino acid variant (K121Q) in the gene encoding the glycoprotein plasma cell differentiating antigen (PC‐1), a specific inhibitor of insulin receptor signalling, has been reported to predict a faster progression of nephropathy in Italian and British type 1 diabetic patients.

Methods. The XbaI and K121Q polymorphisms were determined by PCR‐RFLP in Danish type 1 diabetic patients with nephropathy (122 men/77 women, age 40.9±9.6 years, diabetes duration 27±8 years) and type 1 diabetic patients with persistent normoalbuminuria (118 men/74 women, age 42.7±10.2 years, diabetes duration 26±9 years). Proliferative retinopathy was present in 156 patients (40%), while 67 patients (17%) had no diabetic retinopathy.

Results. There were no differences in the frequency of GLUT‐1 XbaI genotypes between type 1 diabetic patients with diabetic nephropathy and type 1 diabetic patients with normoalbuminuria: 72 (41%)/87 (50%)/16 (9%) vs 94 (49%)/74 (39%)/24 (13%) had GLUT‐1 XbaI +/+, +/− or −/− genotype respectively (NS). The frequency of PC‐1 KK, KQ and QQ genotypes were 141 (71%)/52 (26%)/6 (3%) vs 138 (73%)/45 (24%)/7 (4%) in patients respectively with and without nephropathy (NS). Neither were associations between the investigated polymorphisms and simplex or proliferative retinopathy revealed.

Conclusions. Neither the PC‐1 K121Q nor the GLUT‐1 XbaI polymorphism contribute to the genetic susceptibility of diabetic microvascular complications in Danish type 1 diabetic patients.

Keywords: albuminuria; diabetic nephropathy; diabetic microangiopathy; GLUT‐1 gene; PC‐1 gene; type 1 diabetes

Journal Article.  2228 words. 

Subjects: Nephrology

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