Journal Article

Sympathetic overactivity and arterial hypertension in renal failure

Stephan R. Orth, Kerstin Amann, Kristof Strojek and Eberhard Ritz

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 16, issue suppl_1, pages 67-69
Published in print May 2001 | ISSN: 0931-0509
Published online May 2001 | e-ISSN: 1460-2385 | DOI:
Sympathetic overactivity and arterial hypertension in renal failure

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In the past, it had been presumed that hypertension in chronic renal disease can be explained by the dual effects of sodium retention and inappropriate activity of the renin–angiotensin system. Recent experimental and clinical data provide strong evidence that the increase in blood pressure is to a large part due to sympathetic overactivity which is triggered by afferent signals emanating from the kidney and resetting sympathetic tone by stimulation of hypothalamic centres. The sequelae of sympathetic overactivity extend beyond their effects on blood pressure and include accelerated progression of renal failure and presumably increased cardiac arrhythmia.

Keywords: chronic renal failure; hypertension; metoprolol; moxonidine; sympathetic activity

Journal Article.  0 words. 

Subjects: Nephrology

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