Journal Article

Microalbumin measurement alone or calculation of the albumin/creatinine ratio for the screening of hypertension patients?

Ulla Derhaschnig, Harald Kittler, Christian Woisetschläger, Andreas Bur, Harald Herkner and Michael M. Hirschl

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 17, issue 1, pages 81-85
Published in print January 2002 | ISSN: 0931-0509
Published online January 2002 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/17.1.81
Microalbumin measurement alone or calculation of the albumin/creatinine ratio for the screening of hypertension patients?

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Background. Spot urine sampling seems to be a reliable screening method for the detection of microalbuminuria in hypertensive patients. It remains unclear whether microalbumin measurement alone or calculation of the albumin/creatinine ratio (ACR) are more reliable for the detection of microalbuminuria in non‐selected hypertensive patients.

Methods. Following collection of a spot, midstream urine sample, urine was collected for 24 h for the measurement of microalbumin in 264 hypertensive patients. We compared microalbumin concentration in the spot urine with microalbumin measured in the 24‐h urine sample and examined the utility of the ACR in evaluating microalbuminuria in hypertensive patients. Pathologic microalbuminuria was assumed when the microalbumin concentration exceeded 30 mg/l in the 24‐h urine sample. Diagnostic performance is expressed in terms of specificity, sensitivity, positive (PPV) and negative predictive value (NPV), and area under receiver operating characteristics curve (AUC).

Results. A total of 47 samples (17.8%) showed pathologic microalbuminuria in the 24‐h urine sample. The diagnostic performance expressed as AUC was 0.94 (95% CI 0.90–0.98) for microalbumin measurement alone and 0.94 (95% CI 0.89–0.97) for ACR. The PPV and NPV were 44.2 and 97.9% for microalbumin measurement alone. ACR revealed a PPV of 29.3% and a NPV of 96.2% for males and 42.9 and 98% for females, if a cut‐off value of 2.5 mg/mmol for males and of 4.0 mg/mmol for females was used.

Conclusions. The ACR did not provide any advantage compared with microalbumin measurement alone, but requires an additional determination of creatinine and the use of gender‐specific cut‐off values. Therefore, measurement of microalbuminuria alone in the spot urine sample is more convenient in daily clinical practice and should be used as the screening method for hypertensive patients.

Keywords: microalbuminuria; sensitivity; specificity; spot urine sampling

Journal Article.  2781 words.  Illustrated.

Subjects: Nephrology

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