Journal Article

Cardiovascular calcification in end‐stage renal disease

Isidro B. Salusky and William G. Goodman

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 17, issue 2, pages 336-339
Published in print February 2002 | ISSN: 0931-0509
Published online February 2002 | e-ISSN: 1460-2385 | DOI:
Cardiovascular calcification in end‐stage renal disease

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Cardiovascular diseases are common in patients with end‐stage renal disease (ESRD) and cardiovascular morbidity and mortality among dialysis patients are substantially higher than in the general population. The reasons for this high incidence are multiple. They include traditional factors such as hypertension, diabetes, dyslipidaemia, sodium overload, and elevated homocysteine levels as well as disturbances of mineral metabolism, specifically abnormalities in phosphorus and calcium homeostasis. This review will describe the specific cardiovascular complications related to calcifications in ESRD, the implications of the abnormalities of mineral metabolism in its pathogenesis and the current imaging techniques available for the detection of cardiovascular calcifications. Excess of calcium load contributes to the development of cardiac calcifications; therefore, alternative strategies to diminish exogenous calcium load should be considered in patients with ESRD.

Keywords: cardiovascular calcification; end‐stage renal disease

Journal Article.  2995 words. 

Subjects: Nephrology

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