Journal Article

IV.6 Dialysis fluid purity: implications in the haemocompatibility network system

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 17, issue suppl_7, pages 51-54
Published in print July 2002 | ISSN: 0931-0509
Published online July 2002 | e-ISSN: 1460-2385 | DOI:
IV.6 Dialysis fluid purity: implications in the haemocompatibility network system

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Over the last decade, microbiological contamination of the dialysis fluid has become a major concern [70–72]. In the early 1980s dialysis fluid purity was mainly targeted to prevent pyrogenic reactions associated with the use of bicarbonate buffer and back‐transport phenomena (back‐filtration, back‐diffusion) of dialysis fluid to the blood [73]. From this perspective, the role of the dialyzer membrane is essential to prevent the blood passage of cytokine‐inducing substances from dialysis fluid [74–77] and/or to prevent immunization against dialysis fluid endotoxin [78]. From the late 1990s the dialysis fluid purity was considered as one of the main factors in the complex haemocompatibility network [79–82].

UPD is a concept introduced in the mid 1990s that qualifies a sterile and non‐pyrogenic dialysate produced extemporaneously by ‘cold sterilization’ by means of ultrafilters [83]. Over the last few years it has been recognized that dialysate purity should tend to ultrapure product for contemporary dialysis to prevent the potential hazards associated with contaminated dialysate [84–88].

Guideline IV.6.1

A. Regular use of UPD appears desirable in long‐term haemodialysis patients to prevent and/or to delay the occurrence of dialysis related complications.

(Evidence level: B)

Journal Article.  0 words. 

Subjects: Nephrology

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