Journal Article

Renotropic role and therapeutic potential of HGF in the kidney

Kunio Matsumoto and Toshikazu Nakamura

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 17, issue suppl_9, pages 59-61
Published in print September 2002 | ISSN: 0931-0509
Published online September 2002 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/17.suppl_9.59
Renotropic role and therapeutic potential of HGF in the kidney

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Hepatocyte growth factor (HGF) has mitogenic, morphogenic and anti‐apoptotic activities on renal epithelial cells, and is a potential renotropin for renal regeneration. In chronic renal failure/fibrosis, HGF in the kidney declines in a manner reciprocal to the increase in transforming growth factor‐β (TGF‐β). Neutralization of HGF by the antibody leads to acceleration of renal failure/fibrosis, while HGF administration leads to remarkable attenuation, thus indicating the importance of the balance between HGF and TGF‐β in the pathogenesis and therapy of chronic renal failure. HGF is strongly considered as potential treatment for acute and chronic renal failure.

Keywords: acute renal failure; chronic renal failure; c‐Met; HGF; renal regeneration; renotropin

Journal Article.  0 words. 

Subjects: Nephrology

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