Journal Article

Cardiac troponin I (2nd generation assay) in chronic haemodialysis patients: prevalence and prognostic value

Marta Beciani, Angela Tedesco, Anneo Violante, Silvia Cipriani, Michele Azzarito, Antonio Sturniolo and Giorgio Splendiani

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 18, issue 5, pages 942-946
Published in print May 2003 | ISSN: 0931-0509
Published online May 2003 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfg057
Cardiac troponin I (2nd generation assay) in chronic haemodialysis patients: prevalence and prognostic value

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Background. Elevated serum cardiac troponin T (cTnT) levels are frequently observed in chronic dialysis patients and have been shown to be associated with increased morbidity and mortality. The aim of this study was to determine whether cardiac troponin I (cTnI), which is less frequently elevated, has similar clinical significance.

Methods. We studied 101 asymptomatic patients with no clinical evidence of coronary artery disease who were undergoing chronic dialytic treatment. We measured their serum cTnI levels immediately before the start of their dialysis sessions by a second‐generation assay (OPUS‐DADE). Our study included a year‐long follow‐up with trimestrial cTnI assays as well as clinical, X‐ray and echocardiographic surveillance. We considered patients with serum cTnI ≥0.15 ng/ml as positive and those with levels <0.15 ng/ml as negative.

Results. Among the 14 patients with high serum cTnI levels, nine (64%) suffered acute cardiac events during the 12‐month follow‐up. In contrast, among the 72 patients with low cTnI levels only seven (9.7%) had acute events. In another group of 15 patients with variable cTnI levels, three patients (20%) had cardiac events.

Conclusion. Based on these results, serum cTnI appears to be a valuable predictive marker of cardiovascular events in asymptomatic dialysis patients. For those patients who might benefit from thorough cardiac investigation and treatment, information on cTnI could be useful in preventing cardiac events.

Keywords: cardiac troponin I; myocardial injury; renal disease

Journal Article.  2985 words. 

Subjects: Nephrology

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