Journal Article

Blood 8‐hydroxy‐2′‐deoxyguanosine is associated with erythropoietin resistance in haemodialysis patients

Akihiko Kato, Mari Odamaki and Akira Hishida

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 18, issue 5, pages 931-936
Published in print May 2003 | ISSN: 0931-0509
Published online May 2003 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfg070
Blood 8‐hydroxy‐2′‐deoxyguanosine is associated with erythropoietin resistance in haemodialysis patients

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Background. 8‐Hydroxy‐2′‐deoxyguanosine (8‐OHdG), a product of oxidized DNA, is increased in haemodialysis (HD) patients, but the clinical relevance of enhanced 8‐OHdG production in these patients remains unknown.

Methods. We cross‐sectionally measured serum 8‐OHdG in 73 patients on maintenance HD (age 68±2 years, time on HD 85±11 months, male/female=42/31), and examined the relationship between blood 8‐OHdG and the severity of renal anaemia and the weekly dosage of recombinant human erythropoietin (rHuEPO).

Results. There was a significant increase in serum 8‐OHdG in HD patients compared with normal subjects. Serum 8‐OHdG was positively correlated with the patients' age (r=0.231, P<0.05) but not with the duration of HD. Serum 8‐OHdG was significantly higher in diabetic subjects than in non‐diabetic subjects (P<0.05). Serum 8‐OHdG had a significant inverse correlation with haemoglobin (Hb) (r=−0.526, P<0.01) but a positive correlation with the rHuEPO dose (r=0.443, P<0.01) and the ratio of the weekly rHuEPO dose divided by Hb (r=0.487, P<0.01). Serum 8‐OHdG was not correlated with inflammatory and nutritional parameters.

Conclusions. These findings suggest that the elevation of circulating 8‐OHdG may be associated, at least in part, with rHuEPO resistance in HD patients.

Keywords: anaemia; erythropoietin; haemodialysis; MDA; 8‐OhdG

Journal Article.  3414 words.  Illustrated.

Subjects: Nephrology

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