Journal Article

Adenovirus‐mediated functional gene transfer into parathyroid cells <i>in vivo</i> and <i>in vitro</i>

Yoshiko Iwasaki, Takatoshi Kakuta, Hiroaki Haruguchi, Naoko Fukuda, Kiyoshi Kurokawa and Masafumi Fukagawa

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 18, issue suppl_3, pages iii18-iii22
Published in print June 2003 | ISSN: 0931-0509
Published online June 2003 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfg1005
Adenovirus‐mediated functional gene transfer into parathyroid cells in vivo and in vitro

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Chronic renal failure patients usually develop secondary hyperparathyroidism and, as the disease progresses, there is a decrease in the number of vitamin D and calcium‐sensing receptors (CaRs) in the parathyroid glands. Parathyroid cell function can be controlled if a functional gene is transferred into these cells using an adenovirus vector. Vitamin D or CaR genes transferred by the infected adenovirus vector induced a reduction in parathyroid hormone secretion. These results suggest that adenovirus‐mediated gene transfer is a useful technique for control of parathyroid cell function.

Keywords: adenovirus; calcium‐sensing receptor; functional gene transfer; vitamin D receptor

Journal Article.  1989 words.  Illustrated.

Subjects: Nephrology

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