Journal Article

Genetics of diabetic nephropathy

M. Merta, J. Reiterova, R. Ryšavá, D. Kmentová and V. Tesař

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 18, issue suppl_5, pages v24-v25
Published in print July 2003 | ISSN: 0931-0509
Published online July 2003 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfg1038
Genetics of diabetic nephropathy

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Diabetic nephropathy (DN) develops in ~40% of type 1 diabetic patients and is a leading cause of end-stage renal failure. Its rate of progression varies greatly among individuals. Several factors, including genetic predisposition, metabolic and haemodynamic alterations and various growth factors, may contribute to the initiation and progression of DN. The genetic background of DN is believed to be polygenic. Polymorphisms of different genes, mainly from the renin–angiotensin system, have been studied extensively, and some of them have been suggested to contribute to the development of DN. A search for genes and combinations of genes which could influence the development and progression of DN is in progress.

Keywords: diabetes; diabetic nephropathy; genes; gene polymorphism; IDDM; NIDDM

Journal Article.  1198 words. 

Subjects: Nephrology

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