Journal Article

Podocyte proliferation and differentiation in glomerular disease: role of cell-cycle regulatory proteins

Siân V. Griffin, Arndt T. Petermann, Raghu V. Durvasula and Stuart J. Shankland

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 18, issue suppl_6, pages vi8-vi13
Published in print August 2003 | ISSN: 0931-0509
Published online August 2003 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfg1069
Podocyte proliferation and differentiation in glomerular disease: role of cell-cycle regulatory proteins

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Injury to the podocyte underlies many forms of glomerular disease. In contrast to mesangial and endothelial cells, podocytes do not typically proliferate. Moreover, the lack of proliferation is thought to underlie the development of glomerulosclerosis. Studies have recently shown that the lack of podocyte proliferation is due to an increase in cyclin-dependent kinase inhibitors, which arrest the cell cycle. Current work is aimed at further delineating the mechanisms regulating podocyte proliferation.

Keywords: cell cycle; cyclin; glomerular epithelial cell; kidney; podocyte proliferation

Journal Article.  0 words. 

Subjects: Nephrology

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